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Barbiturates show up to reinforce the metabolism of exogenous corticosteroids most likely with the induction of hepatic microsomal enzymes. Individuals stabilized on corticosteroid therapy may call for dosage changes if barbiturates are extra to or withdrawn from their dosage routine.

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The greater lipid soluble the barbiturate, the greater rapidly it penetrates all tissues of the body. Barbiturates are certain to plasma and tissue proteins to the varying degree Together with the diploma of binding expanding straight like a purpose of lipid solubility.